Abstract :Abstract
Ethan pharmacological relevance: Trichosanthes diociaRoxb.(Family: Cucurbitaceae) has been long used as a folk medicine to treat anti-inflammatory, antihelmintic, skin eruptions, liver congestion, antidiabetic activity of the plant extract.
Materials and Methods: The phytochemical tests to detect the presence of different compounds were based on the visual observation of color change or formation precipitate after the addition of specific reagents. Diabetes was induced in rats by intraperitoneal (i.p.) injection of streptozotocin (STZ) at a dose of 55mg/kg bw. Administration of extract of Trichosanthes diocia (800mg/kg/p.o) were studied for their effect on blood glucose level in streptozotocin induced(55mg/kg/i.p) diabetic rats. The blood glucose levels were estimated by glucometer.
Result: Trichosanthes diocia extract reduced the levels of blood glucose; the study scientifically validates the traditional use of T. diocia in diabetes management and could be developed as an effective oral agent for treating diabetes mellitus.
Conclusions: Trichosanthes diociaexhibits considerable antidiabetic activity. Our study suggests that further detailed studies and mechanism of action of T. dioica would be useful for undertaking human trials.